Elimination Chamber (2010) (also known as No Way Out (2010) in Germany) was a professional wrestling pay-per-view event produced by World Wrestling Entertainment (WWE), which took place on February 21, 2010 at the Scottrade Center in St. Louis, Missouri. It was the first event in the WWE Elimination Chamber series. Six matches were aired on the broadcast and one dark match occurred prior to the live broadcast.
- Dark - Christian defeated Ezekiel Jackson
- John Cena defeated Sheamus (c), Triple H, Randy Orton, Ted DiBiase and Kofi Kingston - Elimination Chamber match for the WWE Championship
- Batista defeated John Cena (c) for the WWE Championship
- Drew McIntyre (c) defeated Kane for the WWE Intercontinental Championship
- LayCool (Michelle McCool and Layla) defeated Maryse and Gail Kim
- The Miz (c) (with Big Show) defeated Montel Vontavious Porter (with Mark Henry) for the WWE United States Championship
- Chris Jericho defeated The Undertaker (c), John Morrison, R-Truth, CM Punk (with Luke Gallows and Serena) and Rey Mysterio - Elimination Chamber match for the WWE World Heavyweight Championship