Mizanin first gained fame as a cast member on MTV's The Real World: Back to New York, which first aired in 2001, and its spinoff series, Real World/Road Rules Challenge. He later entered the fourth season of WWE Tough Enough, a televised competition which awarded the winner a WWE contract, and became the first runner-up. Mizanin has also made appearances on television shows including Battle of the Network Reality Stars, Fear Factor, Identity, Ghost Hunters, Dinner: Impossible, Psych and Are You Smarter Than a 5th Grader?. Mizanin trained and wrestled in independent/developmental territories Ultimate Pro Wrestling, Deep South Wrestling, and Ohio Valley Wrestling prior to appearing in WWE.
Mizanin became host of the annual WWE Diva Search competition in 2006. Following his hosting duties, Mizanin made his wrestling debut in September 2006, as a villain who went undefeated for three months, but his winning streak ended when he was later defeated by the Boogeyman at WWE Armageddon 2006. In 2007, Miz was drafted from SmackDown to the ECW brand, where he formed a partnership with John Morrison, and as a team would go on to win both the WWE Tag Team Championship and World Tag Team Championship.
He was drafted to the Raw brand as part of the 2009 WWE Draft, and won the WWE United States Championship. In July 2010, he won the Raw Money in the Bank ladder match at the first WWE Money in the Bank pay-per-view, earning a contract for a WWE Championship match, which he used in November to win the WWE Championship, which he held for six months. In 2011, The Miz was ranked number one on Pro Wrestling Illustrated's annual PWI 500 list. The Miz has main-evented several pay-per-view events in WWE, including WWE WrestleMania 27.
In total, The Miz has won 13 championships in WWE (one WWE, four Intercontinental, two U.S., and six Tag Team), is the 25th Triple Crown Champion in company history, and (along with John Morrison) won the 2008 Tag Team of the Year Slammy Award.
- Deep South Wrestling Heavyweight Championship
- Ohio Valley Wrestling Southern Tag Team Championship
- WWE Championship
- WWE Intercontinental Championship
- WWE United States Championship
- WWE Tag Team Championship / World Tag Team Championship