Cena started his pro wrestling career in 1999 with Ultimate Pro Wrestling, where he held the UPW Heavyweight Championship. Cena signed a developmental contract with the World Wrestling Federation (WWF, later renamed to WWE) in 2001, debuting on the main roster in 2002. As of March 2015, Cena has won 22 championships, with a record 12 reigns as WWE Champion/WWE World Heavyweight Champion, three reigns as World Heavyweight Champion, three reigns as WWE United States Champion, and a four-time Tag Team Champion (two World Tag Team, and two WWE Tag Team). He also is a 2012 Money in the Bank Match winner, a two-time Royal Rumble winner (2008, 2013), and a three-time Superstar of the Year Slammy Award winner (2009, 2010, 2012).
He has the fourth-highest number of combined days as WWE World Heavyweight Champion, behind Bruno Sammartino, Bob Backlund, and Hulk Hogan. He has also headlined WWE WrestleMania on five occasions (WrestleManias 22, 23, XXVII, XXVIII, and 29) over the course of his career.
Outside of wrestling, Cena has released the rap album You Can't See Me, which debuted at No.15 on the US Billboard 200 chart, and starred in the feature films The Marine (2006), 12 Rounds (2009), and Legendary (2010). Cena has also made appearances on television shows including Manhunt, Deal or No Deal, MADtv, Saturday Night Live, Punk'd, and Psych. Cena was also a contestant on Fast Cars and Superstars: The Gillette Young Guns Celebrity Race, where he made it to the final round before being eliminated, placing third in the overall competition.
- Ohio Valley Wrestling Heavyweight Championship
- Ohio Valley Wrestling Southern Tag Team Championship
- Ultimate Pro Wrestling Heavyweight Championship
- WWE Championship / World Heavyweight Championship
- WWE United States Championship
- WWE World Tag Team Championship / WWE Tag Team Championship