The AWA Brass Knuckles Championship was a professional wrestling championship owned by the American Wrestling Association (AWA) promotion. The championship was introduced on February 12, 1979 at a Mid-South Coliseum live event. It was active until May 1981 when the title belt was abandoned after Crusher Lisowski left the promotion.

It debuted as a part of a storyline to introduce Don Fargo to the Memphis wrestling territory; this allowed Fargo to challenge various wrestlers in hardcore-themed matches. Like most professional wrestling "brass knuckle" championships, both wrestlers would heavily tape their fists to give the impression that each participant were wearing brass knuckles; the title was generally defended in no-disqualification matches and it was legal to punch an opponent. Fargo and Lisowski were the only champions during its original run, with Gino Martino as the first and last champion of the revived AWA Superstars of Wrestling version.

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